Affiliation:
1. Institute of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
Abstract
ABSTRACT
The immune response to lymphocytic choriomeningitis virus in mice lacking macrophage inflammatory protein-1α (MIP-1α) was evaluated. Generation of virus-specific effector T cells is unimpaired in MIP-1α-deficient mice. Furthermore, MIP-1α is not required for T-cell-mediated virus control or virus-induced T-cell-dependent inflammation. Thus, MIP-1α is not mandatory for T-cell-mediated antiviral immunity.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Reference35 articles.
1. Allan, J. E., and P. C. Doherty. 1986. Natural killer cells contribute to inflammation but do not appear to be essential for the induction of clinical lymphocytic choriomeningitis. Scand. J. Immunol.24:153-162.
2. Andersen, I. H., O. Marker, and A. R. Thomsen. 1991. Breakdown of blood-brain barrier function in the murine lymphocytic choriomeningitis virus infection mediated by virus-specific CD8+ T cells. J. Neuroimmunol.31:155-163.
3. Andersson, E. C., J. P. Christensen, O. Marker, and A. R. Thomsen. 1994. Changes in cell adhesion molecule expression on T cells associated with systemic virus infection. J. Immunol.152:1237-1245.
4. Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis
5. Christensen, J. P., E. C. Andersson, A. Scheynius, O. Marker, and A. R. Thomsen. 1995. Alpha 4 integrin directs virus-activated CD8+ T cells to sites of infection. J. Immunol.154:5293-5301.
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献