Identificationof Proteins Associated with Murine Gammaherpesvirus68Virions-Reference-Cited by-同舟云学术

Identificationof Proteins Associated with Murine Gammaherpesvirus68Virions

Published:2003-12-15 Issue:24 Volume:77 Page:13425-13432
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Bortz Eric¹,Whitelegge Julian P.²,Jia Qingmei³,Zhou Z. Hong⁴,Stewart James P.⁵,Wu Ting-Ting³,Sun Ren¹³

Affiliation:

1. Molecular Biology Institute

2. the Pasarow Mass Spectrometry Laboratory, Departments of Psychiatry and Biobehavioral Sciences and The Neuropsychiatric Institute

3. Department of Molecular and Medical Pharmacology, UCLA AIDS Institute, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California 90095

4. Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030

5. Department of Medical Microbiology, University of Liverpool, Liverpool L69 3GA, United Kingdom

Abstract

ABSTRACT Murine gammaherpesvirus 68 (MHV68 [also known asγ HV-68]) is distinguished by its ability to replicate to high titers in cultured cells, making it an excellent candidate for studying gammaherpesvirus virion composition. Extracellular MHV68 virions were isolated, and abundant virion-associated proteins were identified by mass spectrometry. Five nucleocapsid protein homologues, the tegument protein homologue encoded by open reading frame (ORF) 75c, and envelope glycoproteins B and H were detected. In addition, gene products from MHV68 ORF20, ORF24, ORF28, ORF45, ORF48, and ORF52 were identified in association with virions, suggesting that these gammaherpesvirus genes are involved in the early phase of infection or virion assembly and egress.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.77.24.13425-13432.2003

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