Development of a Dual Recombinant Vaccine To Protect Small Ruminants against Peste-des-Petits-Ruminants Virus and Capripoxvirus Infections-Reference-Cited by-同舟云学术

Development of a Dual Recombinant Vaccine To Protect Small Ruminants against Peste-des-Petits-Ruminants Virus and Capripoxvirus Infections

Published:2003-01-15 Issue:2 Volume:77 Page:1571-1577
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Berhe G.¹,Minet C.¹,Le Goff C.¹,Barrett T.²,Ngangnou A.³,Grillet C.¹,Libeau G.¹,Fleming M.²,Black D. N.²,Diallo A.¹

Affiliation:

1. Cirad, Programme Santé Animale, Campus International de Baillarguet, 34398 Montpellier Cedex 05, France

2. Institute of Animal Health, Pirbright Laboratory, Pirbright, Surrey GU 24 ONF, United Kingdom

3. LANAVET, Garoua, Cameroon

Abstract

ABSTRACT A recombinant capripoxvirus vaccine containing a cDNA of the peste-des-petits-ruminants virus (PPRV) fusion protein gene was constructed. A quick and efficient method was used to select a highly purified recombinant virus clone. A trial showed that a dose of this recombinant as low as 0.1 PFU protected goats against challenge with a virulent PPRV strain.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.77.2.1571-1577.2003

Reference30 articles.

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