The AIDS-Like Disease of CD4C/Human Immunodeficiency Virus Transgenic Mice Is Associated with Accumulation of Immature CD11b Hi Dendritic Cells-Reference-Cited by-同舟云学术

The AIDS-Like Disease of CD4C/Human Immunodeficiency Virus Transgenic Mice Is Associated with Accumulation of Immature CD11b Hi Dendritic Cells

Published:2003-11 Issue:21 Volume:77 Page:11733-11744
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Poudrier Johanne¹,Weng Xiaoduan¹,Kay Denis G.¹,Hanna Zaher¹²,Jolicoeur Paul¹³⁴

Affiliation:

1. Laboratory of Molecular Biology, Clinical Research Institute of Montréal, Montréal, Québec H2W 1R7

2. Departments of Medicine

3. Microbiology and Immunology, Université de Montréal, Montréal, Québec H3C 3J7

4. Division of Experimental Medicine, McGill University, Montréal, Québec H3G 1A4, Canada

Abstract

ABSTRACT CD4C/human immunodeficiency virus (HIV) transgenic mice develop an AIDS-like disease. We used this model to study the effects of HIV-1 on dendritic cells (DC). We found a progressive decrease in total DC numbers in the lymph nodes, with a significant accumulation of CD11b Hi DC. In the thymus, the recovery of transgenic CD8α + DC had a tendency to be lower. Spleen DC were augmented in the marginal zone. Transgenic DC showed a decreased capacity to present antigen in vitro, consistent with their reduced major histocompatibility complex class II expression and impaired maturation profile. The accumulation of immature DC may contribute to disease and may reflect an adaptive advantage for the virus by favoring its replication and preventing the generation of fully functional antiviral responses.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.77.21.11733-11744.2003

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