Enterococcus faecalis Gluconate Phosphotransferase System Accelerates Experimental Colitis and Bacterial Killing by Macrophages

Author:

Fan Ting-Jia12,Goeser Laura1,Naziripour Arash1,Redinbo Matthew R.1234,Hansen Jonathan J.125

Affiliation:

1. Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

2. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

3. Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

4. Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

5. Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Abstract

Enterococcus faecalis strains are resident intestinal bacteria associated with invasive infections, inflammatory bowel diseases, and colon cancer. Although factors promoting E. faecalis colonization of intestines are not fully known, one implicated pathway is a phosphotransferase system (PTS) in E. faecalis strain OG1RF that phosphorylates gluconate and contains the genes OG1RF_12399 to OG1RF_12402 (OG1RF_12399-12402).

Funder

UNC | University of North Carolina at Chapel Hill

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference31 articles.

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3. Association of oncogenic bacteria with colorectal cancer in South China

4. Increased Enterococcus faecalis infection is associated with clinically active Crohn disease

5. Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria

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