Cathelicidins Target HSP60 To Restrict CVB3 Transmission via Disrupting the Exosome and Reducing Cardiomyocyte Apoptosis-Reference-Cited by-同舟云学术

Cathelicidins Target HSP60 To Restrict CVB3 Transmission via Disrupting the Exosome and Reducing Cardiomyocyte Apoptosis

Published:2023-03-30 Issue:3 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Yang Yang¹,Huang Chunjing¹,Hui Li²,Song Yahui¹,Fu Yuxuan¹,Li Min¹,Yang Hailong³,Wu Jing³,Sun Jia⁴^ORCID,Xu Wei¹,Wei Lin¹^ORCID

Affiliation:

1. Jiangsu Provincial Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, Jiangsu, China

2. The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu, China

3. School of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan, China

4. State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China

Abstract

The relative mechanisms that cathelicidin antimicrobial peptides use to influence nonenveloped virus infection are unclear. We show here that cathelicidin antimicrobial peptides (CRAMP and LL-37) directly target exosomal HSP60 to destroy exosomes, which in turn block the diffusion of exosomes to recipient cardiomyocytes and reduced HSP60-induced apoptosis, thus restricting coxsackievirus B3 infection.

Funder

National Natural Science Foundation of China

Jiangsu Provincial Key Research and Development Program

Priority Academic Program Development of Jiangsu Higher Education Institutions

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01433-22

Reference52 articles.

1. Antimicrobial peptides of multicellular organisms