Combined Immune Checkpoint Blockade Enhances Antiviral Immunity against Bovine Leukemia Virus

Author:

Nakamura Hayato1,Konnai Satoru123ORCID,Okagawa Tomohiro2,Maekawa Naoya2,Sajiki Yamato1,Watari Kei1,Kamitani Kana4,Saito Maya4,Kato Yukinari56,Suzuki Yasuhiko237,Murata Shiro12,Ohashi Kazuhiko12

Affiliation:

1. Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan

2. Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan

3. Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Japan

4. Hokkaido Hayakita Meat Inspection Center, Hokkaido Government, Abira, Japan

5. Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan

6. Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan

7. Division of Bioresources, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan

Abstract

Enzootic bovine leukosis caused by bovine leukemia virus (BLV) is an important viral disease in cattle, causing severe economic losses to the cattle industry worldwide. The molecular mechanisms of BLV-host interactions are complex.

Funder

MEXT | Japan Society for the Promotion of Science

National Agriculture and Food Research Organization

Ministry of Agriculture, Forestry and Fisheries

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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