Immune Responses to the Mycobacterium tuberculosis -Specific Antigen ESAT-6 Signal Subclinical Infection among Contacts of Tuberculosis Patients-Reference-Cited by-同舟云学术

Immune Responses to the Mycobacterium tuberculosis -Specific Antigen ESAT-6 Signal Subclinical Infection among Contacts of Tuberculosis Patients

Published:2002-02 Issue:2 Volume:40 Page:704-706
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Doherty T. Mark¹,Demissie Abebech²,Olobo Joseph²,Wolday Dawit³,Britton Sven⁴,Eguale Tewodros⁵,Ravn Pernille⁶,Andersen Peter¹

Affiliation:

1. Department of Tuberculosis Immunology, Statens Serum Institute

2. Armauer Hansen Research Institute

3. Black Lion Hospital

4. Karolinska Institute, Stockholm, Sweden

5. Hossana Regional Hospital, Ministry of Health, Hossanna, Ethiopia

6. Hvidovre Hospital, Copenhagen, Denmark

Abstract

ABSTRACT Diagnosis of latent Mycobacterium tuberculosis infection is considered essential for tuberculosis control but is hampered by the lack of specific reagents. We report that strong recognition of tuberculosis complex-specific antigen ESAT-6 by healthy household contacts of tuberculosis patients correlates with the subsequent development of active tuberculosis during a 2-year follow-up period.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.40.2.704-706.2002

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