Intragenic Complementation by Gene 42 Amber Mutations of Bacteriophage T4

Author:

Holmes George E.1

Affiliation:

1. Molecular Biology Program, Department of Microbiology, College of Medicine, University of Arizona, Tucson, Arizona 85724

Abstract

Phage T4 amber mutants defective in gene 42 (dCMP hydroxymethylase) were shown by in vivo and in vitro experiments to participate in both positive and negative intragenic complementation. This argues that incomplete polypeptide chains can participate in subunit interaction.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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