Antimicrobial Susceptibilities of Unique Stenotrophomonas maltophilia Clinical Strains-Reference-Cited by-同舟云学术

Antimicrobial Susceptibilities of Unique Stenotrophomonas maltophilia Clinical Strains

Published:2001-05 Issue:5 Volume:45 Page:1581-1584
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Valdezate Sylvia¹²,Vindel Ana²,Loza Elena¹,Baquero Fernando¹,Cantón Rafael¹

Affiliation:

1. Servicio de Microbiologı́a, Hospital Ramón y Cajal, Madrid-28034,1 and

2. Laboratorio de Infecciones Intrahospitalarias, Centro Nacional de Microbiologı́a. Instituto Carlos III, Majadahonda, Madrid-28220,2 Spain

Abstract

ABSTRACT Susceptibility to 41 antimicrobials was studied with 99 Stenotrophomonas maltophilia strains, and different pulsed-field gel electrophoresis profiles were identified among 130 prospectively collected isolates. Moxalactam, doxycycline, minocycline, and clinafloxacin displayed the highest activity (≥98% susceptibility). Ticarcillin resistance (75%) was reverted by clavulanate in 25% of strains. Trimethoprim-sulfamethoxazole resistance was 26.2% (≥4 [trimethoprim]/76 [sulfamethoxazole] μg/ml) and dropped to 11.1% when an 8/152-μg/ml breakpoint was applied based on its bimodal MIC distribution. Resistance was lower when unique strains were considered, because clonal organisms contribute to resistance.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.5.1581-1584.2001

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