Serotype 19F Multiresistant Pneumococcal Clone Harboring Two Erythromycin Resistance Determinants [ erm (B) and mef (A)] in South Africa-Reference-Cited by-同舟云学术

Serotype 19F Multiresistant Pneumococcal Clone Harboring Two Erythromycin Resistance Determinants [ erm (B) and mef (A)] in South Africa

Published:2001-05 Issue:5 Volume:45 Page:1595-1598
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

McGee Lesley¹,Klugman Keith P.¹,Wasas Avril¹,Capper Thora¹,Brink Adrian²,

Affiliation:

1. MRC/SAIMR/WITS Pneumococcal Diseases Research Unit, South African Institute for Medical Research,1 and

2. Drs DuBuisson, Bruinette and Partners,2 Johannesburg, South Africa

Abstract

ABSTRACT One hundred eighteen erythromycin-resistant Streptococcus pneumoniae (ERSP) strains (MICs of ≥0.5 μg/ml) from five laboratories serving the private sector in South Africa were analyzed for the genes encoding resistance to macrolides. Sixty-seven ERSP strains (56.8%) contained the erm (B) gene, and 15 isolates (12.7%) contained the mef (A) gene. Thirty-six isolates (30.5%) harbored both the erm (B) and mef (A) genes and were highly resistant to erythromycin and clindamycin. DNA fingerprinting by BOX-PCR and pulsed-field gel electrophoresis identified 83% of these strains as belonging to a single multiresistant serotype 19F clone.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.5.1595-1598.2001

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