Macrolide Resistance in Streptococcus pneumoniae in Hong Kong-Reference-Cited by-同舟云学术

Macrolide Resistance in Streptococcus pneumoniae in Hong Kong

Published:2001-05 Issue:5 Volume:45 Page:1578-1580
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ip Margaret¹,Lyon Donald J.¹,Yung Raymond W. H.²,Chan Colin¹,Cheng Augustine F. B.¹

Affiliation:

1. Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin,1 and

2. Pamela Youde Nethersole Eastern Hospital,2 Hong Kong, China

Abstract

ABSTRACT Erythromycin resistance rates among penicillin-susceptible Streptococcus pneumoniae were 38 and 92% among penicillin-intermediate and -resistant S. pneumoniae isolates from Hong Kong, respectively, and 27% (43 of 158) of the isolates showed the MLS B phenotype, and the majority carried the ermB gene; 73% (115 of 158) displayed the M phenotype, and all possessed the mef gene. The MLS B phenotype was predominant in penicillin-susceptible, macrolide-resistant isolates and in penicillin-nonsusceptible isolates of serotype 6B, whilst the M phenotype was predominant in penicillin-intermediate or -resistant isolates belonging to serotype 23F or 19F. Extensive spread of clones of drug-resistant pneumococci has led to the widespread presence of macrolide resistance in S. pneumoniae in Hong Kong.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.5.1578-1580.2001

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