Contribution of YjbIH to Virulence Factor Expression and Host Colonization in Staphylococcus aureus-Reference-Cited by-同舟云学术

Contribution of YjbIH to Virulence Factor Expression and Host Colonization in Staphylococcus aureus

Published:2019-06 Issue:6 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Austin Crystal M.¹,Garabaglu Siamak²,Krute Christina N.¹,Ridder Miranda J.¹,Seawell Nichole A.¹,Markiewicz Mary A.¹,Boyd Jeffrey M.²^ORCID,Bose Jeffrey L.¹

Affiliation:

1. University of Kansas Medical Center, Department of Microbiology, Molecular Genetics and Immunology, Kansas City, Kansas, USA

2. Rutgers, the State University of New Jersey, Department of Biochemistry and Microbiology, New Brunswick, New Jersey, USA

Abstract

To persist within the host and cause disease, Staphylococcus aureus relies on its ability to precisely fine-tune virulence factor expression in response to rapidly changing environments. During an unbiased transposon mutant screen, we observed that disruption of a two-gene operon, yjbIH , resulted in decreased levels of pigmentation and aureolysin (Aur) activity relative to the wild-type strain.

Funder

U.S. Department of Agriculture

HHS | NIH | National Institute of Allergy and Infectious Diseases

National Science Foundation

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00155-19

Reference106 articles.