Thailandamide, a Fatty Acid Synthesis Antibiotic That Is Coexpressed with a Resistant Target Gene-Reference-Cited by-同舟云学术

Thailandamide, a Fatty Acid Synthesis Antibiotic That Is Coexpressed with a Resistant Target Gene

Published:2018-09 Issue:9 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wozniak Christopher E.¹,Lin Zhenjian²,Schmidt Eric W.²,Hughes Kelly T.³,Liou Theodore G.¹^ORCID

Affiliation:

1. Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA

2. College of Pharmacy, Medicinal Chemistry, University of Utah, Salt Lake City, Utah, USA

3. Department of Biology, University of Utah, Salt Lake City, Utah, USA

Abstract

Microbes encode many uncharacterized gene clusters that may produce antibiotics and other bioactive small molecules. Methods for activating these genes are needed to explore their biosynthetic potential.

Funder

Claudia Ruth Goodrich Stevens Endowment Fund

HHS | NIH | National Institute of General Medical Sciences

HHS | NIH | National Heart, Lung, and Blood Institute

Cystic Fibrosis Foundation

Ben B. and Iris M. Margolis Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00463-18

Reference52 articles.

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3. Antibiotics

4. Genome-guided discovery of diverse natural products from Burkholderia sp.

5. Pneumonia and Septicemia Caused by Burkholderia thailandensis in the United States

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