Phase I Study To Evaluate the Pharmacokinetics, Safety, and Tolerability of Two Dosing Regimens of Oral Fosfomycin Tromethamine in Healthy Adult Participants-Reference-Cited by-同舟云学术

Phase I Study To Evaluate the Pharmacokinetics, Safety, and Tolerability of Two Dosing Regimens of Oral Fosfomycin Tromethamine in Healthy Adult Participants

Published:2018-08 Issue:8 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wenzler Eric¹^ORCID,Bleasdale Susan C.²,Sikka Monica²,Bunnell Kristen L.¹^ORCID,Finnemeyer Matthew³,Rosenkranz Susan L.³,Danziger Larry H.¹²,Rodvold Keith A.¹²,

Affiliation:

1. College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA

2. College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

3. Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA

Abstract

The pharmacokinetics (PK), safety, and tolerability of two repeated dosing regimens of oral fosfomycin tromethamine were evaluated in 18 healthy adult subjects. Subjects received 3 g every other day (QOD) for 3 doses and then every day (QD) for 7 doses, or vice versa, in a phase I, randomized, open-label, two-period-crossover study.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00464-18

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4. Fosfomycin

5. Evaluation of three-dose fosfomycin tromethamine in the treatment of patients with urinary tract infections: an uncontrolled, open-label, multicentre study

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