Elevated Nitric Oxide Production in Children with Malarial Anemia: Hemozoin-Induced Nitric Oxide Synthase Type 2 Transcripts and Nitric Oxide in Blood Mononuclear Cells-Reference-Cited by-同舟云学术

Elevated Nitric Oxide Production in Children with Malarial Anemia: Hemozoin-Induced Nitric Oxide Synthase Type 2 Transcripts and Nitric Oxide in Blood Mononuclear Cells

Published:2004-08 Issue:8 Volume:72 Page:4868-4873
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Keller Christopher C.¹,Kremsner Peter G.²³,Hittner James B.⁴,Misukonis Mary A.⁵,Weinberg J. Brice⁵,Perkins Douglas J.¹

Affiliation:

1. Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania

2. Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon

3. Department of Parasitology, Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany

4. Department of Psychology, College of Charleston, Charleston, South Carolina

5. Department of Medicine, Durham VA and Duke University Medical Centers, Durham, North Carolina

Abstract

ABSTRACT Experiments outlined here investigate the role of nitric oxide (NO) in the pathogenesis of Plasmodium falciparum -induced malarial anemia (MA). The results show that ex vivo and in vitro NO synthase (NOS) activity in peripheral blood mononuclear cells (PBMCs) is significantly elevated in children with MA and inversely associated with hemoglobin levels. Additional experiments using PBMCs from non-malaria-exposed donors demonstrate that physiologic amounts of P. falciparum -derived hemozoin augment NOS type 2 (NOS2) transcripts and NO production. Results of these experiments illustrate that elevated NO production in children with MA is associated with decreased hemoglobin concentrations and that hemozoin can induce NOS2-derived NO formation in cultured blood mononuclear cells.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.72.8.4868-4873.2004

Reference33 articles.

1. Agbenyega, T., B. Angus, G. Beduaddo, B. Baffoebonnie, G. Griffin, P. Vallance, and S. Krishna. 1997. Plasma nitrogen oxides and blood lactate concentrations in Ghanaian children with malaria. Trans. R. Soc. Trop. Med. Hyg.91:298-302.

2. Al-Yaman, F., M. M. Awburn, and I. A. Clark. 1997. Serum creatinine levels and reactive nitrogen intermediates in children with cerebral malaria in Papua New Guinea. Trans. R. Soc. Trop. Med. Hyg.91:303-305.

3. Al-Yaman, F. M., D. Mokela, B. Genton, K. A. Rockett, M. P. Alpers, and I. A. Clark. 1996. Association between serum levels of reactive nitrogen intermediates and coma in children with cerebral malaria in Papua New Guinea. Trans. R. Soc. Trop. Med. Hyg.90:270-273.

4. Anstey, N. M., D. L. Granger, M. Y. Hassanali, E. D. Mwaikambo, P. E. Duffy, and J. B. Weinberg. 1999. Nitric oxide, malaria, and anemia: inverse relationship between nitric oxide production and hemoglobin concentration in asymptomatic, malaria-exposed children. Am. J. Trop. Med. Hyg.61:249-252.

5. Anstey, N. M., J. B. Weinberg, M. Hassanali, E. D. Mwaikambo, D. Manyenga, M. A. Misukonis, D. R. Arnelle, D. Hollis, M. I. McDonald, and D. L. Granger. 1996. Nitric oxide in Tanzanian children with malaria. Inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. J. Exp. Med.184:557-567.

Cited by 78 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Erythropoiesis and Malaria, a Multifaceted Interplay;International Journal of Molecular Sciences;2022-10-23

2. Ingestion of hemozoin by peripheral blood mononuclear cells alters temporal gene expression of ubiquitination processes;Biochemistry and Biophysics Reports;2022-03

3. High Prevalence of Asymptomatic Malarial Anemia and Association with Early Conversion from Asymptomatic to Symptomatic Infection in a Plasmodium falciparum Hyperendemic Setting in Cameroon;The American Journal of Tropical Medicine and Hygiene;2022-01-05

4. Exploring the mechanism of Buxue Yimu Pill on hemorrhagic anemia through molecular docking, network pharmacology and experimental validation;Chinese Journal of Natural Medicines;2021-12

5. Transcriptome-based analysis of blood samples reveals elevation of DNA damage response, neutrophil degranulation, cancer and neurodegenerative pathways in Plasmodium falciparum patients;Malaria Journal;2021-09-26