Clinical and Molecular Characterization of Invasive Heteroresistant Vancomycin-Intermediate Staphylococcus aureus Infections in Korean Hospitals

Author:

Kim Eu Suk12,Bae In-Gyu3,Cho Jeong Eun1,Choi Yun Jung1,Kim Il-Hwan4,Kang Gi-Su4,Sin Hye-yun1,Song Kyoung-Ho12,Park Chulmin5,Lee Dong-Gun56ORCID,Kim Moonsuk12,Park Kyoung Un7,Kim Hong Bin12ORCID

Affiliation:

1. Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea

2. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea

3. Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea

4. Division of Antimicrobial Resistance, Center for Infectious Diseases, Korea National Institute of Health, KCDC, Cheongju, South Korea

5. Vaccine Bio Research Institute, The Catholic University of Korea, Seoul, South Korea

6. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea

7. Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea

Abstract

ABSTRACT Invasive heteroresistant vancomycin-intermediate Staphylococcus aureus (h-VISA) isolates were identified and characterized in 10 Korean hospitals from July 2009 to June 2011. The prevalence of h-VISA infections was 3.3% (42/1,289). Most (41/42) were health care-associated infections caused by strains belonging to sequence type 5. Cases of persistent bacteremia were frequent (17/42), and 30-day mortality was high (16/40).

Funder

Seoul National University Bundang Hospital

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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