Population Pharmacokinetic Study of Ceftriaxone in Elderly Patients, Using Cystatin C-Based Estimates of Renal Function To Account for Frailty-Reference-Cited by-同舟云学术

Population Pharmacokinetic Study of Ceftriaxone in Elderly Patients, Using Cystatin C-Based Estimates of Renal Function To Account for Frailty

Published:2020-09-21 Issue:10 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Tan Shu Jin¹²,Cockcroft Matthew³,Page-Sharp Madhu⁴,Arendts Glenn³,Davis Timothy M. E.³^ORCID,Moore Brioni R.³⁴,Batty Kevin T.⁴,Salman Sam³^ORCID,Manning Laurens¹³

Affiliation:

1. Department of Infectious Diseases, Fiona Stanley Hospital, Murdoch, Western Australia, Australia

2. Department of Infectious Diseases, Royal Perth Hospital, Perth, Western Australia, Australia

3. Faculty of Medicine and Health Sciences, University of Western Australia, Perth, Western Australia, Australia

4. School of Pharmacy and Biomedical Sciences, Curtin University, Perth, Western Australia, Australia

Abstract

Ceftriaxone is widely used for respiratory and urinary infections in elderly and frail patients, but there are few pharmacokinetic studies. A prospective population pharmacokinetic study of ceftriaxone in adults over 65 years old was undertaken. Dried blood spots collected at baseline (predose) and 0.5, 1, 4, 8, and 24 h after administration of 1 g of ceftriaxone were assayed using a validated liquid chromatography-mass spectroscopy analytical method. Frailty was classified using the Edmonton frailty scale and grip strength via a hand dynamometer.

Funder

Department of Health | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00874-20

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