Activity of Moxifloxacin, Imipenem, and Ertapenem against Escherichia coli, Enterobacter cloacae, Enterococcus faecalis, and Bacteroides fragilis in Monocultures and Mixed Cultures in anIn VitroPharmacokinetic/Pharmacodynamic Model Simulating Concentrations in the Human Pancreas

Abstract

ABSTRACTThe activities of moxifloxacin, imipenem, and ertapenem against pathogens causing severe necrotizing pancreatitis were studied in anin vitropharmacokinetics/pharmacodynamics (PK/PD) model.Escherichia coli,Enterobacter cloacae,Enterococcus faecalis, andBacteroides fragiliswere exposed in monocultures and mixed cultures to concentrations of the three agents comparable to those in the human pancreas. Moxifloxacin was more active than the two carbapenems in monocultures and mixed cultures, reducing the numbers of CFU more drastically and more rapidly.