Penicillin-Binding Proteins and Alternative Dual-Beta-Lactam Combinations for Serious Enterococcus faecalis Infections with Elevated Penicillin MICs-Reference-Cited by-同舟云学术

Penicillin-Binding Proteins and Alternative Dual-Beta-Lactam Combinations for Serious Enterococcus faecalis Infections with Elevated Penicillin MICs

Published:2023-02-16 Issue:2 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cusumano Jaclyn A.¹^ORCID,Daffinee Kathryn E.¹,Ugalde-Silva Paul²,Peti Wolfgang³,Arthur Michel⁴⁵⁶^ORCID,Desbonnet Charlene²,Rice Louis B.²^ORCID,LaPlante Kerry L.¹⁷⁸^ORCID,García-Solache Mónica²

Affiliation:

1. Infectious Diseases Research Program, Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA

2. Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA

3. Department of Molecular Biology and Biophysics, UConn Health, Farmington, Connecticut, USA

4. Centre de Recherche des Cordeliers, INSERM, UMRS 1138, Paris, France

5. Sorbonne Université, UMR S 1138, Paris, France

6. Université Paris Cité, UMR S 1138, Paris, France

7. College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, USA

8. Warren Alpert Medical School of Brown University, Division of Infectious Diseases, Providence, Rhode Island, USA

Abstract

Ampicillin-ceftriaxone has become a first-line therapy for Enterococcus faecalis endocarditis. We characterized the penicillin-binding protein (PBP) profiles of various E. faecalis strains and tested for synergy to better inform beta-lactam options for the treatment of E. faecalis infections.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00871-22

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