Serologic Response to Borrelia Antigens Varies with Clinical Phenotype in Children and Young Adults with Lyme Disease

Author:

Radtke Felix A.12ORCID,Ramadoss Nitya3,Garro Aris45,Bennett Jonathan E.6,Levas Michael N.7,Robinson William H.38,Nigrovic Peter A.19,Nigrovic Lise E.10ORCID

Affiliation:

1. Division of Rheumatology, Inflammation, and Immunity, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

2. Department of Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany

3. Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA

4. Department of Emergency Medicine, Rhode Island Hospital and Brown University, Providence, Rhode Island, USA

5. Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, Rhode Island, USA

6. Division of Emergency Medicine, A.I. Dupont Hospital for Children, Wilmington, Delaware, USA

7. Division of Emergency Medicine, Children’s Hospital of Wisconsin, Milwaukee, Wisconsin, USA

8. VA Palo Alto Health Care System, Palo Alto, California, USA

9. Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

10. Division of Emergency Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

Abstract

Lyme disease is commonly diagnosed by serologic response to Borrelia burgdorferi and related species, but the relationship between serologic targets and clinical features is unknown. We developed a multiantigen Luminex-based panel and evaluated IgG responses in 527 children 1 to 21 years of age assessed for Lyme disease across 4 Pedi Lyme Net emergency departments, including 127 Lyme cases defined by either an erythema migrans (EM) lesion or positive C6 enzyme immunoassay followed by immunoblotting and 400 patients considered clinical mimics.

Funder

Joint Biology Consortium

Bay Area Lyme Foundation

Boehringer Ingelheim Fonds

Global Lyme Alliance

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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