Application of a Fas Ligand Encoding a Recombinant Adenovirus Vector for Prolongation of Transgene Expression-Reference-Cited by-同舟云学术

Application of a Fas Ligand Encoding a Recombinant Adenovirus Vector for Prolongation of Transgene Expression

Published:1998-03 Issue:3 Volume:72 Page:2483-2490
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Zhang Huang-Ge¹²,Bilbao Guadalupe¹,Zhou Tong²,Contreras Juan Luis¹³,Gómez-Navarro Jesús¹,Feng Meizhen¹,Saito Izumu⁴,Mountz John D.²,Curiel David T.¹

Affiliation:

1. Gene Therapy Program,1

2. Department of Rheumatology,2 and

3. Department of Surgery,3 University of Alabama at Birmingham, Birmingham, Alabama 35294, and

4. Laboratory of Molecular Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan4

Abstract

ABSTRACT An adenovirus vector encoding murine Fas ligand (mFasL) under an inducible control was derived. In vivo ectopic expression of mFasL in murine livers induced an inflammatory cellular infiltration. Furthermore, ectopic expression of mFasL by myocytes did not allow prolonged vector-mediated transgene expression. Thus, ectopic expression of functional mFasL in vector-transduced cells does not appear to confer, by itself, an immunoprivileged site sufficient to mitigate adenovirus vector immunogenicity.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.72.3.2483-2490.1998

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