Analysis of the Brucella suis Twin Arginine Translocation System and Its Substrates Shows That It Is Essential for Viability-Reference-Cited by-同舟云学术

Analysis of the Brucella suis Twin Arginine Translocation System and Its Substrates Shows That It Is Essential for Viability

Published:2023-01-24 Issue:1 Volume:91 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Riquelme Elia¹²,Omarova Sabina¹²,Ize Bérengère³,O’Callaghan David¹²^ORCID

Affiliation:

1. VBIC, INSERM U1047, UFR Médecine, Université de Montpellier, Nimes, France

2. CNR Brucella, CHU Nimes, Nimes, France

3. LISM-UMR7255 CNRS, Institut de Microbiologie de la Méditerranée, Aix-Marseille Université, Marseille, France

Abstract

Bacteria use the twin arginine translocator (Tat) system to export folded proteins from the cytosol to the bacterial envelope or to the extracellular environment. As with most Gram-negative bacteria, the Tat system of the zoonotic pathogen Brucella spp. is encoded by a three-gene operon, tatABC. Our attempts, using several different strategies, to create a Brucella suis strain 1330 tat mutant were all unsuccessful.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00459-22

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