High Mobility Group Protein 1 Reverses Immune System Paralysis in Late-Phase Sepsis-Reference-Cited by-同舟云学术

High Mobility Group Protein 1 Reverses Immune System Paralysis in Late-Phase Sepsis

Published:2018-09 Issue:9 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Liu Qing-yang¹²,Wang Yue-Xin³,Wu Zong-Sheng⁴,Shi Zhen-wei¹,Wu Xu⁵,Chen Xin⁶,Yang Zhao⁷,Xu Kai-zhi⁸

Affiliation:

1. Department of Translational Medicine and Nephrology, China Meitan General Hospital, Beijing, China

2. Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing, China

3. First Department of Orthopedics, Tangshan Worker's Hospital Affiliated to Hebei Medical University, Tangshan, Hebei Province, China

4. Department of Emergency, Zhongda Hospital Affiliated to Southeast University, Nanjing, China

5. Becton-Dickinson Biosciences, Beijing, China

6. Department of Oncology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei Province, China

7. College of Chemistry, Beijing Normal University, Beijing, China

8. Department of Anesthesiology, Tangshan Worker's Hospital Affiliated to Hebei Medical University, Tangshan, Hebei Province, China

Abstract

High mobility group protein 1 (HMGB1) is considered to be the primary inflammatory factor triggering immune paralysis in late-phase sepsis. In this study, however, we wanted to explore the possibility of using HMGB1 to boost local differentiation of bone marrow cells (BMCs) into regulatory dendritic cells (DCs) in vivo , thereby inducing immune reversal in late-phase sepsis and improving the prognosis.

Funder

National Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00455-18

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