Multiple Genes of Candida albicans Influencing Echinocandin Susceptibility in Caspofungin-Adapted Mutants-Reference-Cited by-同舟云学术

Multiple Genes of Candida albicans Influencing Echinocandin Susceptibility in Caspofungin-Adapted Mutants

Published:2022-12-20 Issue:12 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Sah Sudisht K.¹,Bhattacharya Soumyaroop²³,Yadav Anshuman¹,Husain Farha¹,Ndiaye Aissatou B. K. T.¹,Kruppa Michael D.⁴,Hayes Jeffrey J.¹,Rustchenko Elena¹^ORCID

Affiliation:

1. Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York, USA

2. Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA

3. Center for Pediatric Biochemical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA

4. Department of Biomedical Sciences, Center of Excellence in Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA

Abstract

Candida albicans is an opportunistic human fungal pathogen that causes invasive infections in immunocompromised individuals. Despite the high anticandidal activity among the echinocandins (ECNs), a first-line therapy, resistance remains an issue.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00977-22

Reference48 articles.

1. Transcriptional regulation of the caspofungin-induced cell wall damage response in Candida albicans

2. Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond

3. Resistance of Candida to azoles and echinocandins worldwide