Structural and Biochemical Features of OXA-517: a Carbapenem and Expanded-Spectrum Cephalosporin Hydrolyzing OXA-48 Variant-Reference-Cited by-同舟云学术

Structural and Biochemical Features of OXA-517: a Carbapenem and Expanded-Spectrum Cephalosporin Hydrolyzing OXA-48 Variant

Published:2023-02-16 Issue:2 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Dabos Laura¹²,Raczynska Joanna E.³,Bogaerts Pierre⁴,Zavala Agustin⁵,Girlich Delphine¹²,Bonnin Remy A.¹²,Dortet Laurent¹²⁶^ORCID,Peyrat Aurélie¹,Retailleau Pascal⁵,Iorga Bogdan I.⁵^ORCID,Jaskólski Mariusz³⁷,Glupczynski Youri⁴,Naas Thierry¹²⁶^ORCID

Affiliation:

1. Team “Resist” UMR1184, INSERM, CEA, University Paris-Saclay, LabEx LERMIT, Faculty of Medicine, Le Kremlin-Bicêtre, France

2. French National Reference Center for Antibiotic Resistance: Carbapenemase-producing Enterobacterales, Le Kremlin-Bicêtre, France

3. Center for Biocrystallographic Research, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland

4. Laboratory of Clinical Microbiology, National Reference Center for Monitoring Antimicrobial Resistance in Gram-Negative Bacteria, CHU UCL Namur, Yvoir, Belgium

5. Université Paris-Saclay, CNRS UPR 2301, Institut de Chimie des Substances Naturelles, Labex LERMIT, Gif-sur-Yvette, France

6. Department of Bacteriology-Hygiene, Bicêtre Hospital, APHP Paris-Saclay, Le Kremlin-Bicêtre, France

7. Department of Crystallography, Faculty of Chemistry, A. Mickiewicz University, Poznan, Poland

Abstract

OXA-48-producing Enterobacterales have now widely disseminated throughout the world. Several variants have now been reported, differing by just a few amino-acid substitutions or deletions, mostly in the region of the loop β5-β6.

Funder

i2BC Crystallization Platform

DIM Maladie Infectieuse

Agence Nationale de la Recherche

Assistance Publique - Hôpitaux de Paris

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01095-22

Reference66 articles.