Microbial 7α-Hydroxylation of 3-Ketobisnorcholenol-Reference-Cited by-同舟云学术

Microbial 7α-Hydroxylation of 3-Ketobisnorcholenol

Published:1986-05 Issue:5 Volume:51 Page:946-949
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Despreaux Carl W.¹,Rittweger Karen R.¹,Palleroni Norberto J.¹

Affiliation:

1. Department of Microbiology, Hoffmann-La Roche, Inc., Roche Research Center, Nutley, New Jersey 07110

Abstract

The transformation of 22-hydroxy-23,24-bisnorchol-4-en-3-one to 7α-22-dihydroxy-23,24-bisnorchol-4-en-3-one by Botryodiploida theobromae, Lasiodiplodia theobromae , and various Botryosphaeria strains is described. Factors affecting the reaction were incubation temperature, sonication of the substrate, and addition of 2,2′-dipyridyl, extra carbohydrate, and Amberlite XAD-7. The enzyme responsible for the reaction appeared to be very specific and was not characteristic of all members of the genera listed above.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/aem.51.5.946-949.1986

Reference24 articles.

1. Microbiological hydroxylation of 4- androstene-3,17-dione;Abul-Hajj Y. J.;Lloydia,1970

2. Microbial transformation of sterols. I. Decomposition of cholesterol by microorganisms;Arima K.;Agric. Biol. Chem.,1969

3. Microbial hydroxylation. XXIII. Hydroxylations of fluoro-5ot-androstanones by the fungi Calonectria decora, Rhizopus nigricans, and Aspergillus ochraceus;Bird T. G. C.;J. Chem. Soc. Perkin Trans.,1980

4. Charney W. and H. L. Herzog. 1967. Microbial transformations of steroids p. 396. Academic Press Inc. New York.

5. Microbial transformations of 3a-acetoxy-17a-aza-D-homo-5a-androstan-17-one and of 3a-acetoxy-5a-androstan-17-one with the fungus Cunninghamella elegans;Crabb T. A.;J. Chem. Soc. Perkin Trans.,1977

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