Affiliation:
1. Department of Chemistry, Florida State University, Tallahassee, Florida
Abstract
Shapira, Jacob
(Department of Chemistry, Florida State University, Tallahassee)
and Karl Dittmer
. Unsaturated amino acids. V. Microbiological properties of some halogenated olefinic amino acids. J. Bacteriol.
82:
640–647. 1961.—It has been shown previously that several amino acid analogues containing unsaturated linkages were inhibitors of the growth of
Escherichia coli
and
Saccharomyces cerevisiae
. This paper reports the results obtained when a series of unsaturated halogen-containing amino acids was examined. The
cis
isomer of ω-chloroallylglycine showed the greatest toxicity yet found in this series of unsaturated amino acids toward
E. coli
, whereas the
trans
-isomer was usually far less toxic. The major effect of
cis
-ω-chloroallylglycine in
E. coli
appeared to be to extend the lag phase before the normal rate of growth began. A wide variety of amino acids was capable of partially or completely preventing the toxicity of low levels of these compounds. At higher levels, relatively few amino acids (primarily valine, leucine, and glutamic acid) were effective. In
E. coli, cis
-ω-chloroallylglycine showed an unusual [Formula: see text] relationship with both glutamic acid and valine over a wide range in concentration.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
3 articles.
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