UNSATURATED AMINO ACIDS V

Author:

Shapira Jacob1,Dittmer Karl1

Affiliation:

1. Department of Chemistry, Florida State University, Tallahassee, Florida

Abstract

Shapira, Jacob (Department of Chemistry, Florida State University, Tallahassee) and Karl Dittmer . Unsaturated amino acids. V. Microbiological properties of some halogenated olefinic amino acids. J. Bacteriol. 82: 640–647. 1961.—It has been shown previously that several amino acid analogues containing unsaturated linkages were inhibitors of the growth of Escherichia coli and Saccharomyces cerevisiae . This paper reports the results obtained when a series of unsaturated halogen-containing amino acids was examined. The cis isomer of ω-chloroallylglycine showed the greatest toxicity yet found in this series of unsaturated amino acids toward E. coli , whereas the trans -isomer was usually far less toxic. The major effect of cis -ω-chloroallylglycine in E. coli appeared to be to extend the lag phase before the normal rate of growth began. A wide variety of amino acids was capable of partially or completely preventing the toxicity of low levels of these compounds. At higher levels, relatively few amino acids (primarily valine, leucine, and glutamic acid) were effective. In E. coli, cis -ω-chloroallylglycine showed an unusual [Formula: see text] relationship with both glutamic acid and valine over a wide range in concentration.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference21 articles.

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3. The structural basis of some amino acid antagonists and their microbiological properties;DITTMER K.;Ann. N. Y. Acad. Sci.,1950

4. The inhibition of microbiological growth by allylglycine, methallylglycine and crotylglycine;DITTMER K., H.;J. Am. Chem. Soc.,1948

5. Studies on the niutrition and metabolism of Pasteurella pestis;DOUDOROFF M.;PIroc. Soc. Exptl. Biol. Med.,1943

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