Therapeutic Efficacy of Novel Antimicrobial Peptide AA139-Nanomedicines in a Multidrug-Resistant Klebsiella pneumoniae Pneumonia-Septicemia Model in Rats-Reference-Cited by-同舟云学术

Therapeutic Efficacy of Novel Antimicrobial Peptide AA139-Nanomedicines in a Multidrug-Resistant Klebsiella pneumoniae Pneumonia-Septicemia Model in Rats

Published:2020-08-20 Issue:9 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

van der Weide Hessel¹^ORCID,Cossío Unai²,Gracia Raquel³,te Welscher Yvonne M.⁴,ten Kate Marian T.¹,van der Meijden Aart¹,Marradi Marco³⁵,Ritsema Jeffrey A. S.⁴,Vermeulen-de Jongh Denise M. C.¹,Storm Gert⁴,Goessens Wil H. F.¹,Loinaz Iraida³,van Nostrum Cornelus F.⁴,Llop Jordi²⁶,Hays John P.¹,Bakker-Woudenberg Irma A. J. M.¹

Affiliation:

1. Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam (Erasmus MC), Rotterdam, The Netherlands

2. Radiochemistry and Nuclear Imaging Group, CIC biomaGUNE, Donostia-San Sebastián, Spain

3. CIDETEC, Basque Research and Technology Alliance (BRTA), Donostia-San Sebastián, Spain

4. Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

5. Department of Chemistry “Ugo Schiff,” University of Florence, Florence, Italy

6. CIBER de Enfermedades Respitorias (CIBERES), Madrid, Spain

Abstract

Antimicrobial peptides (AMPs) have seen limited clinical use as antimicrobial agents, largely due to issues relating to toxicity, short biological half-life, and lack of efficacy against Gram-negative bacteria. However, the development of novel AMP-nanomedicines, i.e., AMPs entrapped in nanoparticles, has the potential to ameliorate these clinical problems. The authors investigated two novel nanomedicines based on AA139, an AMP currently in development for the treatment of multidrug-resistant Gram-negative infections.

Funder

EU | Seventh Framework Programme

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00517-20

Reference44 articles.

1. Trends in mortality from pneumonia in the Europe union: a temporal analysis of the European detailed mortality database between 2001 and 2014

2. Clinical and economic burden of community-acquired pneumonia among adults in Europe

3. Antimicrobial susceptibility of Gram-negative organisms isolated from patients hospitalised with pneumonia in US and European hospitals: Results from the SENTRY Antimicrobial Surveillance Program, 2009–2012