Macrolide Antibiotic-Mediated Downregulation of MexAB-OprM Efflux Pump Expression in Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Macrolide Antibiotic-Mediated Downregulation of MexAB-OprM Efflux Pump Expression in Pseudomonas aeruginosa

Published:2008-11 Issue:11 Volume:52 Page:4141-4144
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Sugimura Makoto¹,Maseda Hideaki²,Hanaki Hideaki³,Nakae Taiji³

Affiliation:

1. Graduate School of Medical Science, Kitasato Institute University, 1-15-1 Kitasato, Sagamihara 228-8555, Japan

2. Department of Biological Science and Technology, Faculty of Engineering, 2-1 Minamijyousanjima-cho, Tokushima 770-8605, Japan

3. Laboratory for Anti-infectious Drugs, Kitasato Institute University, Bldg. S-105, 1-15-1 Kitasato, Sagamihara 228-8555, Japan

Abstract

ABSTRACT Macrolide antibiotics modulate the quorum-sensing system of Pseudomonas aeruginosa . We tested the effect of macrolide antibiotics on the cell density-dependent expression of the MexAB-OprM efflux pump and found that 1.0 μg/ml (MIC/6.25) of azithromycin suppressed the expression of MexAB-OprM by about 70%, with the result that the cells became two- to fourfold more susceptible to antibiotics such as aztreonam, tetracycline, carbenicillin, chloramphenicol, and novobiocin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00511-08

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