Dual Effect in the Mechanism of Action of Anti-Influenza Virus Amino Acid Analogues

Author:

Fujita Haruhisa1

Affiliation:

1. Division of Chemotherapy, Pharmaceutical Institute, School of Medicine, Keio University, Shinanomachi Shinjuku, Tokyo 160, Japan

Abstract

In comparative research studies to clarify the mechanism governing the effects of anti-influenza amino acid analogues, it was established that amino acid analogues exhibit definite chemotherapeutic properties. They possess dual activity capable of inhibiting multiplication and pulmonary consolidation induced by influenza virus infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference12 articles.

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1. Synthesis and antiviral activity of N- and O-acyl derivatives of threo-DL-phenylserine;Pharmaceutical Chemistry Journal;1993-05

2. Natural Products;Chemotherapy of Viral Infections;1982

3. Antiviral agents;Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques;1978

4. Mechanism of Action of Anti-Influenza Benzamidine Derivatives;Antimicrobial Agents and Chemotherapy;1975-04

5. Syntheses of Aminoacid Derivatives and Their Biological Activities.I. Anti-Influenza Activity;YAKUGAKU ZASSHI;1975

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