Monocyte-Derived Interleukin-10 Depresses the Bordetella pertussis - Specific Gamma Interferon Response in Vaccinated Infants-Reference-Cited by-同舟云学术

Monocyte-Derived Interleukin-10 Depresses the Bordetella pertussis - Specific Gamma Interferon Response in Vaccinated Infants

Published:2009-12 Issue:12 Volume:16 Page:1816-1821
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Dirix V.¹,Verscheure V.¹,Goetghebuer T.²,Hainaut M.²,Debrie A. S.³⁴,Locht C.³⁴,Mascart F.¹⁵

Affiliation:

1. Laboratory of Vaccinology and Mucosal Immunity

2. Department of Pediatrics, Hôpital Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium

3. INSERM U629, F-59019 Lille, France

4. Institut Pasteur de Lille, F-59019 Lille, France

5. Immunobiology Clinic, Hôpital Erasme

Abstract

ABSTRACT Antigen-specific gamma interferon (IFN-γ) has been demonstrated to participate in protection against Bordetella pertussis infection. Circulating mononuclear cells from B. pertussis -infected and from pertussis-vaccinated infants secrete high amounts of IFN-γ after in vitro stimulation by B. pertussis antigens, but with a large variation in the secreted IFN-γ levels between individuals. We show here that the inhibition of the specific IFN-γ response can be at least partially attributed to IL-10 secretion by monocytes. This IL-10 secretion was not associated with polymorphisms at positions −1082, −819, and −592 of the IL-10 gene promoter, suggesting that other genetic or environmental factors affect IL-10 expression and secretion.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00314-09

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