Emergence of VIM-2 and IMP-15 Carbapenemases and Inactivation ofoprDGene in Carbapenem-Resistant Pseudomonas aeruginosa Clinical Isolates from Lebanon

Abstract

ABSTRACTWe report here the emergence of VIM-2 and IMP-15 carbapenemases in a series of clinical isolates of carbapenem-resistantPseudomonas aeruginosain Lebanon. We also describe the disruption of theoprDgene by either mutations or insertion sequence (IS) elements ISPa1328and ISPre2isoform. Our study reemphasizes a rapid dissemination of the VIM-2 carbapenemase-encoding gene in clinical isolates ofP. aeruginosain the Mediterranean basin.