Treatment with Bumped Kinase Inhibitor 1294 Is Safe and Leads to Significant Protection against Abortion and Vertical Transmission in Sheep Experimentally Infected with Toxoplasma gondii during Pregnancy-Reference-Cited by-同舟云学术

Treatment with Bumped Kinase Inhibitor 1294 Is Safe and Leads to Significant Protection against Abortion and Vertical Transmission in Sheep Experimentally Infected with Toxoplasma gondii during Pregnancy

Published:2019-07 Issue:7 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Sánchez-Sánchez Roberto¹,Ferre Ignacio¹,Re Michela¹²,Ramos Juan José³,Regidor-Cerrillo Javier¹,Pizarro Díaz Manuel²,González-Huecas Marta²,Tabanera Enrique²,Benavides Julio⁴,Hemphill Andrew⁵,Hulverson Matthew A.⁶,Barrett Lynn K.⁶,Choi Ryan⁶,Whitman Grant R.⁶,Ojo Kayode K.⁶,Van Voorhis Wesley C.⁶,Ortega-Mora Luis Miguel¹^ORCID

Affiliation:

1. SALUVET, Animal Health Department, Faculty of Veterinary Sciences, Complutense University of Madrid, Madrid, Spain

2. Department of Animal Medicine and Surgery, Faculty of Veterinary Sciences, Complutense University of Madrid, Madrid, Spain

3. Departamento de Patología Animal. Facultad de Veterinaria C/Miguel Servet 177, Zaragoza, Spain

4. Instituto de Ganadería de Montaña (CSIC-Universidad de León), León, Spain

5. Institute of Parasitology, Vetsuisse Faculty, University of Bern, Berne, Switzerland

6. Center for Emerging and Reemerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA

Abstract

Previous studies on drug efficacy showed low protection against abortion and vertical transmission of Toxoplasma gondii in pregnant sheep. Bumped kinase inhibitors (BKIs), which are ATP-competitive inhibitors of calcium-dependent protein kinase 1 (CDPK1), were shown to be highly efficacious against several apicomplexan parasites in vitro and in laboratory animal models.

Funder

United States Department of Agriculture

HHS | National Institutes of Health

Ministerio de Educación, Cultura y Deporte

Comunidad de Madrid

Swiss Re Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02527-18