Effects of 5-Fluorouracil and 5-Fluorodeoxyuridine on Growth and Tumor-Inducing Ability of Agrobacterium tumefaciens

Author:

Beardsley Robert E.1,Lipetz Jacques1

Affiliation:

1. Laboratory of Plant Morphogenesis, Manhattan College, Bronx, New York

Abstract

Beardsley, Robert E. (Manhattan College, Bronx, N.Y.), and Jacques Lipetz Effects of 5-fluorouracil and 5-fluorodeoxyuridine on growth and tumor-inducing ability of Agrobacterium tumefaciens . J. Bacteriol. 92: 346–348. 1966.— Agrobacterium tumefaciens B6, grown in the presence of 5-fluorouracil or 5-fluodeoxyuridine, exhibited a prolonged lag phase. The tumor-inducing ability of bacteria grown in the presence of these compounds was decreased even after exposures as short as 40 min. A positive correlation was found between the growth-inhibitory effects of these compounds and their effects on the tumor-inducing ability of the bacteria.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference10 articles.

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2. Induction tumorale et son inhibition;M.;Bull. Soc. Franc. Physiol. Vegetale.,1964

3. Tumor inception and development in the crown gall disease;BRAUN A. C.;Ann. Rev. Plant Physiol.,1962

4. Influence of compounds with antitumor activity on crown gall;LANG J.;Phytopathology,1966

5. Effect of 5-bromuracil on crown gall tumour induction;LIPETZ J.;Nature,1961

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