Clinical isolate of Citrobacter freundii highly resistant to new quinolones-Reference-Cited by-同舟云学术

Clinical isolate of Citrobacter freundii highly resistant to new quinolones

Published:1988-06 Issue:6 Volume:32 Page:922-924
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Aoyama H¹,Fujimaki K¹,Sato K¹,Fujii T¹,Inoue M¹,Hirai K¹,Mitsuhashi S¹

Affiliation:

1. Episome Institute, Gunma, Japan.

Abstract

About 30% of 150 recent clinical isolates of Citrobacter freundii were resistant to greater than or equal to 3.13 micrograms of norfloxacin and ofloxacin per ml. Study of one quinolone-resistant strain for which the norfloxacin MIC was 100 micrograms/ml suggested that resistance was associated with both an altered A subunit of DNA gyrase and reduction in drug uptake accompanied by a decrease in an outer membrane protein.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.32.6.922

Reference23 articles.

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