Destruction of Intracellular Trypanosoma cruzi After Treatment of Infected Macrophages with Cationic Electron Carriers

Author:

Alves Maria Julia M.1,Rabinovitch Michel1

Affiliation:

1. Division of Parasitology and Department of Cell Biology, New York University School of Medicine, New York, New York 10016

Abstract

Intracellular forms of Trypanosoma cruzi were destroyed in infected mouse macrophage cultures treated for 24 h with micromolar concentrations of phenazine methosulfate, brilliant cresyl blue, or crystal violet. Parasites were not killed in macrophages which were only treated with the dyes before infection, indicating that the drugs did not induce a protracted state of macrophage trypanocidal activity.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference13 articles.

1. Active oxygen species and the functions of phagocytic leukocytes. Annu;Badwey J. A.;Rev. Biochem.,1980

2. Growth and differentiation in Trypanosoma cruzi. I. Origin of metacyclic trypanosomes in liquid media;Camargo E. P.;Rev. Inst. Med. Trop. Sao Paulo,1964

3. Oxygen toxicity in Streptococ cus sanguis. The relative importance of superoxide and hydroxyl radicals;DiGuiseppi J.;J. Biol. Chem.,1982

4. Generation of free radicals from phenazine methosulfate in Trypanosorna criuzi epimastigotes;Docampo R.;Acta Trop.,1978

5. Intracellular parasites and phagocytic cells: cell biology and pathophysiology;Edelson P. J.;Rev. Infect. Dis.,1982

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