Affiliation:
1. Department of Physiological Chemistry, University of California, Los Angeles, California
Abstract
Adler, Richard
H. (University of California, Los Angeles)
and John E. Snoke
. Requirement of divalent metal ions for bacitracin activity. J. Bacteriol.
83:
1315–1317. 1962.—The antibiotic activity of bacitracin towards
Staphylococcus aureus
is completely suppressed by ethylenediaminetetraacetate. The conclusion that bacitracin activity requires the presence of metal ions is supported by the demonstration that the addition of a number of divalent ions reverses the effect of ethylenediaminetetraacetate. The most active of these ions, cadmium, manganese, and zinc, directly enhance the activity of bacitracin.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference4 articles.
1. ABRAHAM E. P. 1957. Biochemistry of some peptide and steroid antibiotics. John Wiley and Sons Inc. New York.
2. The assay of bacitracin;DARKER G. D.;J. Am. Pharm. Assoc. Sci. Ed.,1948
3. Bacitracin: a new antibiotic produced by a member of the B. subtilis group;JOHNSON B. A.;Science,1945
4. Enhancement of bacitracin by the metallic ions of group II B;WEINBERG E. D.;Antibiotics Ann.,1959
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