Affiliation:
1. Institute of Experimental Immunology, University of Zürich, Switzerland.
Abstract
Cytotoxic T-lymphocyte (CTL) and T-helper-cell responses in various mouse strains were monitored. Protective CTL responsiveness against three proteins of vesicular stomatitis virus was H-2 linked and inducible only in half of the 15 combinations tested (each of five H-2 haplotypes combined with each of three viral proteins), whereas biologically relevant T-helper-cell responses were inducible in all. This suggests that vesicular stomatitis virus exhibits more T-helper-cell than CTL epitopes.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Reference20 articles.
1. Antiviral protection by CD8+ versus CD4+ T cells: CD8+ T cells correlating with cytotoxic activity in vitro are more efficient in antivaccinia virus protection than CD4-dependent interleukins;Binder D.;J. Immunol.,1991
2. T cell response to viral and bacterial infection;Blanden R. V.;Transplant. Rev.,1974
3. Antibodies against the two serotypes of vesicular stomatitis virus measured by enzyme-linked immunosorbent assay: immunodominance of serotype-specific determinants and induction of asymmetrically cross-reactive antibodies;Charan S.;J. Virol.,1987
4. Antibody mediated suppression of secondary IgM response in nude mice against vesicular stomatitis virus;Charan S.;J. Immunol.,1986
5. Therapy with monoclonal antibodies by elimination of T cell subsets in vivo;Cobbold S. P.;Nature (London),1984
Cited by
31 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献