A single amino acid substitution in the V1 loop of human immunodeficiency virus type 1 gp120 alters cellular tropism-Reference-Cited by-同舟云学术

A single amino acid substitution in the V1 loop of human immunodeficiency virus type 1 gp120 alters cellular tropism

Published:1993-06 Issue:6 Volume:67 Page:3649-3652
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Boyd M T¹,Simpson G R¹,Cann A J¹,Johnson M A¹,Weiss R A¹

Affiliation:

1. Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom.

Abstract

Specific point mutations which affect viral tropism have been identified in both the V3 loop and in the CD4-binding region of the human immunodeficiency virus type 1 surface glycoprotein gp120. Here we report that a single point mutation in the first variable region (V1) of human immunodeficiency virus type 1 strain JRCSF is responsible for a change in viral tropism.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.67.6.3649-3652.1993

Reference30 articles.

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