Improved characterization of aminoglycoside penetration into human lung epithelial lining fluid via population pharmacokinetics-Reference-Cited by-同舟云学术

Improved characterization of aminoglycoside penetration into human lung epithelial lining fluid via population pharmacokinetics

Published:2024-02-07 Issue:2 Volume:68 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Shin Eunjeong¹,Zhang Yongzhen¹,Zhou Jieqiang¹,Lang Yinzhi¹,Sayed Alaa R. M.¹,Werkman Carolin¹,Jiao Yuanyuan²,Kumaraswamy Monika³⁴,Bulman Zackery P.⁵^ORCID,Luna Brian M.⁶,Bulitta Jürgen B.¹^ORCID

Affiliation:

1. Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Orlando, Florida, USA

2. Peking University Cancer Hospital, Beijing, China

3. Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California, USA

4. Infectious Diseases Section, VA San Diego Healthcare System, San Diego, California, USA

5. Department of Pharmacy Practice, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois, USA

6. Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA

Abstract

ABSTRACT Aminoglycosides are important treatment options for serious lung infections, but modeling analyses to quantify their human lung epithelial lining fluid (ELF) penetration are lacking. We estimated the extent and rate of penetration for five aminoglycosides via population pharmacokinetics from eight published studies. The area under the curve in ELF vs plasma ranged from 50% to 100% and equilibration half-lives from 0.61 to 5.80 h, indicating extensive system hysteresis. Aminoglycoside ELF peak concentrations were blunted, but overall exposures were moderately high.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01393-23

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