Therapeutic Effects of Intravitreously Administered Bacteriophage in a Mouse Model of Endophthalmitis Caused by Vancomycin-Sensitive or -Resistant Enterococcus faecalis-Reference-Cited by-同舟云学术

Therapeutic Effects of Intravitreously Administered Bacteriophage in a Mouse Model of Endophthalmitis Caused by Vancomycin-Sensitive or -Resistant Enterococcus faecalis

Published:2019-11 Issue:11 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kishimoto Tatsuma¹^ORCID,Ishida Waka¹,Fukuda Ken¹,Nakajima Isana¹,Suzuki Takashi²,Uchiyama Jumpei³,Matsuzaki Shigenobu¹⁴,Todokoro Daisuke⁵,Daibata Masanori⁴,Fukushima Atsuki¹

Affiliation:

1. Department of Ophthalmology and Visual Science, Kochi Medical School, Kochi University, Kochi, Japan

2. Department of Ophthalmology, Toho University, Tokyo, Japan

3. Laboratory of Veterinary Microbiology I, School of Veterinary Medicine, Azabu University, Kanagawa, Japan

4. Department of Microbiology and Infection, Kochi Medical School, Kochi University, Kochi, Japan

5. Department of Ophthalmology, Gunma University Graduate School of Medicine, Gunma, Japan

Abstract

Endophthalmitis due to infection with Enterococcus spp. progresses rapidly and often results in substantial and irreversible vision loss. Given that the frequency of this condition caused by vancomycin-resistant Enterococcus faecalis has been increasing, the development of novel therapeutics is urgently required.

Funder

MEXT | Japan Society for the Promotion of Science

Novartis Pharma Research Grants 2017

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01088-19

Reference46 articles.

1. Microbiologic Factors and Visual Outcome in the Endophthalmitis Vitrectomy Study

2. Endophthalmitis Caused by Enterococcus faecalis: Clinical Features, Antibiotic Sensitivities, and Outcomes