In Vitro Activity of Tedizolid Compared to Linezolid and Five Other Antimicrobial Agents against 332 Anaerobic Isolates, Including Bacteroides fragilis Group, Prevotella , Porphyromonas , and Veillonella Species-Reference-Cited by-同舟云学术

In Vitro Activity of Tedizolid Compared to Linezolid and Five Other Antimicrobial Agents against 332 Anaerobic Isolates, Including Bacteroides fragilis Group, Prevotella , Porphyromonas , and Veillonella Species

Published:2020-08-20 Issue:9 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Goldstein Ellie J. C.¹²^ORCID,Merriam C. Vreni¹,Citron Diane M.¹

Affiliation:

1. R. M. Alden Research Laboratory, Santa Monica, California, USA

2. The David Geffen School of Medicine at UCLA, Los Angeles, California, USA

Abstract

Tedizolid’s anaerobic activity is unappreciated. In this study, it was active against all 332 anaerobic isolates tested at ≤2 μg/ml except Bilophila wadsworthia and was more active than linezolid against Bacteroides fragilis group species (MIC 90 , 1 μg/ml versus 2 to 4 μg/ml). Tedizolid was active against Gram-positive anaerobes (MIC 90 for clostridia, 0.25 to 1 μg/ml; MIC 90 for anaerobic cocci, ≤0.

Funder

Bayer

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01088-20

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