Genetic Context of optrA and poxtA in Florfenicol-Resistant Enterococci Isolated from Flowing Surface Water in Switzerland-Reference-Cited by-同舟云学术

Genetic Context of optrA and poxtA in Florfenicol-Resistant Enterococci Isolated from Flowing Surface Water in Switzerland

Published:2021-09-17 Issue:10 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Biggel Michael¹^ORCID,Nüesch-Inderbinen Magdalena¹^ORCID,Jans Christoph²,Stevens Marc J. A.¹,Stephan Roger¹^ORCID

Affiliation:

1. Institute for Food Safety and Hygiene, Vetsuisse Faculty University of Zürich, Zürich, Switzerland

2. Amt für Verbraucherschutz, Steinhausen, Zug, Switzerland

Abstract

Linezolid is an important last-resort antibiotic for the treatment of multidrug-resistant enterococci. The aim of this study was to further characterize the genetic context of optrA and poxtA in 10 florfenicol-resistant enterococci isolated from flowing surface water. In most genomes, optrA and poxtA were embedded in transposition units integrated into plasmids or into the chromosomal radC . For the first time, a chromosomally integrated optrA in an Enterococcus raffinosus isolate is described.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01083-21

Reference24 articles.

1. Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe: Towards a common nomenclature

2. The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning

3. The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A Antibiotics

4. Characterization of poxtA, a novel phenicol–oxazolidinone–tetracycline resistance gene from an MRSA of clinical origin

5. A novel gene, optrA, that confers transferable resistance to oxazolidinones and phenicols and its presence in Enterococcus faecalis and Enterococcus faecium of human and animal origin

Cited by 14 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Risk Factor Analysis for Occurrence of Linezolid-Resistant Bacteria in the Digestive and Respiratory Tract of Food-Producing Animals in Belgium: A Pilot Study;Antibiotics;2024-07-29

2. Private and well drinking water are reservoirs for antimicrobial resistant bacteria;npj Antimicrobials and Resistance;2024-03-18

3. Mapping the widespread distribution and transmission dynamics of linezolid resistance in humans, animals, and the environment;Microbiome;2024-03-13

4. Transferable linezolid resistance genes (optrA and poxtA) in enterococci derived from livestock compost at Japanese farms;Journal of Global Antimicrobial Resistance;2024-03

5. Global spread of the linezolid-resistant Enterococcus faecalis ST476 clonal lineage carrying optrA;Journal of Antimicrobial Chemotherapy;2024-02-15