Epidemiological and Clinical Characteristics of International Travelers with Enteric Fever and Antibiotic Resistance Profiles of Their Isolates: a GeoSentinel Analysis

Author:

Hagmann Stefan H. F.12ORCID,Angelo Kristina M.3,Huits Ralph4,Plewes Katherine5,Eperon Gilles6,Grobusch Martin P.7,McCarthy Anne8,Libman Michael9,Caumes Eric10,Leung Daniel T.11ORCID,Asgeirsson Hilmir1213,Jensenius Mogens14,Schwartz Eli1516,Sánchez-Montalvá Adrian17,Kelly Paul18,Pandey Prativa19,Leder Karin2021,Bourque Daniel L.2223,Yoshimura Yukihiro24,Mockenhaupt Frank P.2526,van Genderen Perry J. J.27,Odolini Silvia2829,Schlagenhauf Patricia30,Connor Bradley A.31,Hamer Davidson H.323334

Affiliation:

1. Steven and Alexandra Cohen Children’s Medical Center, North Shore-LIJ Health System, Division of Pediatric Infectious Diseases, New Hyde Park, New York, USA

2. Donald and Barbara Zucker School of Medicine, Hofstra University/Northwell Health, New Hempstead, New York, USA

3. Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

4. Institute of Tropical Medicine, Antwerp, Belgium

5. Division of Infectious Diseases, University of British Columbia, Vancouver, Canada

6. Division of Tropical and Humanitarian Medicine, Department of Primary Care, Geneva University Hospitals, Geneva, Switzerland

7. Center of Tropical Medicine and Travel Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands

8. Ottawa Hospital and Department of Medicine, University of Ottawa, Ottawa, Canada

9. J. D. MacLean Centre for Tropical Diseases, McGill University, Montreal, Canada

10. Service des Maladies Infectieuses et Tropicales, Hopital Pitie Salpetriere, Paris, France

11. International Travel Clinic and Division of Infectious Diseases, University of Utah School of Medicine, Salt Lake City, Utah, USA

12. Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden

13. Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden

14. Oslo University, Department of Infectious Diseases, Oslo, Norway

15. Center for Geographic Medicine, Sheba Medical Center at Tel Ha-Shomer, Ramat Gan, Israel

16. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

17. Infectious Diseases Department, Hospital Universitario Vall d’Hebron, Universidad Autónoma de Barcelona, PROSICS, Barcelona, Spain

18. Bronx-Lebanon Hospital Center, Bronx, New York, USA

19. CIWEC Hospital, Travel Medicine Center, Kathmandu, Nepal

20. School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia

21. Victorian Infectious Diseases Service, Melbourne Health, Parkville, Victoria, Australia

22. Division of Infectious Diseases and Travel Medicine, Mount Auburn Hospital, Cambridge, Massachusetts, USA

23. Harvard Medical School, Boston, Massachusetts, USA

24. Department of Infectious Diseases, Yokohama Municipal Citizen’s Hospital, Yokohama, Japan

25. Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

26. Berlin Institute of Health, Institute of Tropical Medicine and International Health, Berlin, Germany

27. Institute for Tropical Diseases, University Hospital Erasmus MC, Rotterdam, The Netherlands

28. University Department of Infectious and Tropical Diseases, University of Brescia, Brescia, Italy

29. Spedali Civili General Hospital, Brescia, Italy

30. WHO Collaborating Centre for Travel Medicine, Travel Clinic and Department of Public and Global Health, Epidemiology, Biostatistics and Prevention Institute, University of Zürich, Zürich, Switzerland

31. The New York Center for Travel and Tropical Medicine, Weill Cornell Medical College, New York, New York, USA

32. Department of Global Health, Boston University School of Public Health, Boston, Massachusetts, USA

33. Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA

34. National Emerging Infectious Disease Laboratory, Boston, Massachusetts, USA

Abstract

Enteric fever, caused by Salmonella enterica serovar Typhi ( S . Typhi) and S. enterica serovar Paratyphi ( S . Paratyphi), is a common travel-related illness. Limited data are available on the antimicrobial resistance (AMR) patterns of these serovars among travelers. Records of travelers with a culture-confirmed diagnosis seen during or after travel from January 2007 to December 2018 were obtained from GeoSentinel. Traveler demographics and antimicrobial susceptibility data were analyzed.

Funder

HHS | Centers for Disease Control and Prevention

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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