Isolation of a gene required for programmed initiation of development by Aspergillus nidulans

Author:

Adams T H1,Hide W A1,Yager L N1,Lee B N1

Affiliation:

1. Department of Biology, Texas A&M University, College Station 77843.

Abstract

In contrast to many other cases in microbial development, Aspergillus nidulans conidiophore production initiates primarily as a programmed part of the life cycle rather than as a response to nutrient deprivation. Mutations in the acoD locus result in "fluffy" colonies that appear to grow faster than the wild type and proliferate as undifferentiated masses of vegetative cells. We show that unlike wild-type strains, acoD deletion mutants are unable to make conidiophores under optimal growth conditions but can be induced to conidiate when growth is nutritionally limited. The requirement for acoD in conidiophore development occurs prior to activation of brlA, a primary regulator of development. The acoD transcript is present both in vegetative hyphae prior to developmental induction and in developing cultures. However, the effects of acoD mutations are detectable only after developmental induction. We propose that acoD activity is primarily controlled at the posttranscriptional level and that it is required to direct developmentally specific changes that bring about growth inhibition and activation of brlA expression to result in conidiophore development.

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Reference29 articles.

1. briA is necessary and sufficient to direct conidiophore development in Aspergillus nidulans;Adams T. H.;Cell,1988

2. Developmental repression of growth and gene expression in Aspergllus;Adams T. H.;Proc. Natl. Acad. Sci. USA,1990

3. Upstream elements repress premature expression of an Aspergillus developmental regulatory gene;Adams T. H.;Mol. Cell. Biol.,1990

4. .Adams T. H. and W. E. Timberlake. Unpublished data.

5. Kinetics of differentiation of conidiophores and conidia by colonies ofAspergillus nidulans;Axelrod D. E.;J. Gen. Microbiol.,1972

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3