Affiliation:
1. Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Abstract
Previous work had identified a corepressor, NAB1, which represses transcriptional activation mediated by NGFI-A (also known as Egr-1, zif268, and Krox24) and Krox20. These zinc finger transcription factors are encoded by immediate-early genes and have been implicated in a wide variety of proliferative and differentiative processes. We have isolated and characterized another corepressor, NAB2, which is highly related to NAB1 within two discrete domains. The first conserved domain of NAB2 mediates an interaction with the R1 domain of NGFI-A. NAB2 represses the activity of both NGFI-A and Krox20, and its expression is regulated by some of the same stimuli that induce NGFI-A expression, including serum stimulation of fibroblasts and nerve growth factor stimulation of PC12 cells. The human NAB2 gene has been localized to chromosome 12ql3.3-14.1, a region that is rearranged in several solid tumors, lipomas, uterine leiomyomata, and liposarcomas. Sequencing of the Caenorhabditis elegans genome has identified a gene that bears high homology to both NAB1 and NAB2, suggesting that NAB molecules fulfill an evolutionarily conserved role.
Publisher
American Society for Microbiology
Subject
Cell Biology,Molecular Biology
Reference58 articles.
1. Basic local alignment search tool;Altschul S. F.;J. Mol. Biol.,1990
2. .Apel E. Unpublished data.
3. The Prosite dictionary of sites and patterns in proteins, its current status;Bairoch A.;Nucleic Acids Res.,1993
4. Suppression of tumorigenicity of human prostate cancer cells by introduction of human chromosome del(12)(q13);Bérubé N. G.;Cancer Res.,1994
5. Cytomegalovirus plasmid vectors for permanent lines of polarized epithelial cells;Brewer C. B.;Methods Cell Biol.,1994
Cited by
272 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献