Chagas Disease Serological Test Performance in U.S. Blood Donor Specimens-Reference-Cited by-同舟云学术

Chagas Disease Serological Test Performance in U.S. Blood Donor Specimens

Published:2019-12 Issue:12 Volume:57 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Whitman Jeffrey D.¹,Bulman Christina A.²,Gunderson Emma L.²,Irish Amanda M.³,Townsend Rebecca L.⁴,Stramer Susan L.⁴,Sakanari Judy A.²,Bern Caryn³

Affiliation:

1. Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA

2. Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, USA

3. Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA

4. Scientific Affairs, American Red Cross, Gaithersburg, Maryland, USA

Abstract

Chagas disease affects an estimated 300,000 individuals in the United States. Diagnosis in the chronic phase requires positive results from two different IgG serological tests. Three enzyme-linked immunosorbent assays (ELISAs) (Hemagen, Ortho, and Wiener) and one rapid test (InBios) are FDA cleared, but comparative data in U.S. populations are sparse. We evaluated 500 seropositive and 300 seronegative blood donor plasma samples.

Funder

Mundo Sano Foundation

HHS | NIH | National Heart, Lung, and Blood Institute

Bill and Melinda Gates Foundation

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01217-19

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