Sicca Syndrome Associated with Tropheryma whipplei Intestinal Infection

Author:

Bosman Cesare1,Boldrini Renata2,Borsetti Giuliana3,Morelli Sergio3,Paglia Maria Grazia4,Visca Paolo45

Affiliation:

1. Department of Experimental Medicine and Pathology

2. Department of Pathology, Bambino Gesù Pediatric Hospital

3. Department of Medical Sciences, “La Sapienza” University

4. Molecular Microbiology Unit, National Institute for Infectious Diseases, “Lazzaro Spallanzani,” IRCCS

5. Department of Biology, “Roma Tre” University, Rome, Italy

Abstract

ABSTRACT The case of a 61-year-old woman with Whipple's disease-associated sicca complex is reported. Tropheryma whipplei infection was diagnosed by histological and ultrastructural examination of the jejunal mucosa and sequence analysis of the bacterial 16S ribosomal DNA. The role of vitamin A malabsorption in sicca complex secondary to Whipple's disease is discussed.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference19 articles.

1. Anderson, M. 2000. Neurology of Whipple's disease. J. Neurol. Neurosurg. Psychiatry68:2-5.

2. Aragona, P., G. Magazzu, G. Macchia, S. Bartolone, G. Di Pasquale, C. Vitali, and G. Ferreri. 1999. Presence of antibodies against Helicobacter pylori and its heat-shock protein 60 in the serum of patients with Sjogren's syndrome. J. Rheumatol.26:1306-1311.

3. Duggan, C., and S. Nurko. 1997. “Feeding the gut”: the scientific basis for continued enteral nutrition during acute diarrhea. J. Pediatr.131:801-808.

4. Whipple's Disease

5. Fleming Cole, N., E. C. Toy, and B. Baker. 2001. Sjogren's syndrome. Prim. Care Update Ob. Gyns.8:48-51.

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