Corneal Ulcer Caused by the New Fungal Species Sarcopodium oculorum

Author:

Guarro Josep12,Höfling-Lima Ana Luisa3,Gené Josepa12,De Freitas Denise3,Godoy Patricio4,Zorat-Yu Maria Luisa3,Zaror Luis5,Fischman Olga4

Affiliation:

1. Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut

2. Institut d'Estudis Avançats, Universitat Rovira i Virgili, 43201 Reus, Tarragona, Spain

3. Disciplina de Oftalmología

4. Disciplina de Biología Celular, UNIFESP/EPM, São Paulo, Brazil

5. Instituto de Microbiología Clínica, Universidad Austral de Chile, Valdivia, Chile

Abstract

ABSTRACT We describe a case of keratitis caused by a new species of the hyphomycetous genus Sarcopodium , S. oculorum . The corneal ulcer developed after 5 months of treatment with corticosteroids in a Brazilian boy diagnosed with allergic conjunctivitis. Fungal hyphae and conidia were detected in corneal scrapings, and repeated cultures were positive for this fungus. The infection was resolved with natamycin and ketoconazole. Eleven antifungals were tested against this fungus, and all except flucytosine and fluconazole showed in vitro activity.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference13 articles.

1. Behrens-Braumann, W. 1999. Mycosis of the eye and its adnexa. Dev. Ophthalmol.32:i-ix, 1-201.

2. De Hoog G. S. J. Guarro J. Gené and M. J. Figueras. 2000. Atlas of clinical fungi 2nd ed. Centraalbureau voor Schimmelcultures Utrecht The Netherlands and the Rovira i Virgili University Reus Spain.

3. Ellis M. B. 1976. More dematiaceous hyphomycetes. Commonwealth Mycological Institute Kew United Kingdom.

4. Foster, C. S. 1992. Fungal keratitis. Infect. Dis. Clin. N. Am.6:851-857.

5. Gené, J., and J. Guarro. 1996. A new Chaetomium from Thailand. Mycol. Res.100:1005-1009.

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